If amphetamines exert their effects via G-Protein Coupled Receptors (GPCRs) like TAARs, then doesn’t their use optimize homeostatic mechanisms involved in dopaminergic signaling?

Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains Link to direct file Underhill, Suzanne M., et al. “Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains.” Molecular psychiatry 26.4 (2021): 1208-1223. Significance of this work My goal here is to convey the extremely paired … Read more

Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges

Geerts, H., Wikswo, J., van der Graaf, P. H., Bai, J. P., Gaiteri, C., Bennett, D., … & Pelleymounter, M. (2020). Quantitative systems pharmacology for neuroscience drug discovery and development: current status, opportunities, and challenges. CPT: pharmacometrics & systems pharmacology, 9(1), 5-20. https://doi.org/10.1002/psp4.12478

Translational BioInformatics in Mental Health: open access data sources and computational biomarker discovery

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Prescription Drug Monitoring Programs (PDMPs), Prescribing & Dispensing Policies | Do they function to mediate help or harm?

“Overall, opiod prescribing rates have been shown to decrease in some states after implementation of PDMPs, but no significant changes have been found in others. Studies on the effects of PDMPs on opiod overdoses have similarly been mixed with some studies finding no chance in overdose following PDMP implementation, and others finding an increase in overdose. In addition, there has been considerable concern among researchers that the rise in heroin use and overdose starting in 2010 may have been an unintended consequence of policies like the PDMP that reduced the supply of prescription opioids for non-medical use.

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