Higher Morbidity & Mortality Associated with Prescription Drug Monitoring Programs in 3 States | What is the Problem We Are Trying To Solve Again?

Effects of Implementation and Enforcement Differences in Prescription Drug Monitoring Programs in 3 States: Connecticut, Kentucky, and Wisconsin   Before analyzing the outcomes of the implementation of PDMPs and related drug control policies, let’s back track to the ‘problem’ for which these public health interventions were created to address: “Drug Misuse” is commonly defined as … Read more

Article 27

  What is Article 27? The Universal Declaration of Human Rights, adopted by the UN General Assembly on 10 December 1948, includes an article that supports the human right to participate in science through education, advocacy, and the development of open tools for self-research. This article, known as Article 27, has been largely neglected but … Read more

What is Learning?

Maybe lifelong learning can be best conceptualized as a way of engaging with people and with ideas and that naturally mediates a particular epistemic attitude; that attitude being a loving, non-attachment toward one’s appraisal of knowledge and the process of learning. In other words, learning is a good in itself, uncompromised by the irrational desire to see “oneself” in a certain way. 

If amphetamines exert their effects via G-Protein Coupled Receptors (GPCRs) like TAARs, then doesn’t their use optimize homeostatic mechanisms involved in dopaminergic signaling?

Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders.

Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains Link to direct file Underhill, Suzanne M., et al. “Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains.” Molecular psychiatry 26.4 (2021): 1208-1223. Significance of this work My goal here is to convey the extremely paired … Read more

Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges

Geerts, H., Wikswo, J., van der Graaf, P. H., Bai, J. P., Gaiteri, C., Bennett, D., … & Pelleymounter, M. (2020). Quantitative systems pharmacology for neuroscience drug discovery and development: current status, opportunities, and challenges. CPT: pharmacometrics & systems pharmacology, 9(1), 5-20. https://doi.org/10.1002/psp4.12478

Prescription Drug Monitoring Programs (PDMPs), Prescribing & Dispensing Policies | Do they function to mediate help or harm?

“Overall, opiod prescribing rates have been shown to decrease in some states after implementation of PDMPs, but no significant changes have been found in others. Studies on the effects of PDMPs on opiod overdoses have similarly been mixed with some studies finding no chance in overdose following PDMP implementation, and others finding an increase in overdose. In addition, there has been considerable concern among researchers that the rise in heroin use and overdose starting in 2010 may have been an unintended consequence of policies like the PDMP that reduced the supply of prescription opioids for non-medical use.

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