What is Learning?

Maybe lifelong learning can be best conceptualized as a way of engaging with people and with ideas and that naturally mediates a particular epistemic attitude; that attitude being a loving, non-attachment toward one’s appraisal of knowledge and the process of learning. In other words, learning is a good in itself, uncompromised by the irrational desire to see “oneself” in a certain way. 

If amphetamines exert their effects via G-Protein Coupled Receptors (GPCRs) like TAARs, then doesn’t their use optimize homeostatic mechanisms involved in dopaminergic signaling?

Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders.

Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains Link to direct file Underhill, Suzanne M., et al. “Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains.” Molecular psychiatry 26.4 (2021): 1208-1223. Significance of this work My goal here is to convey the extremely paired … Read more

What does Democratizing Science and Medicine mean?

The current state of science and technology excludes many individuals from participating, despite the potential for technology to democratize these fields. This exclusion perpetuates inequities and undermines the scientific enterprise itself.

Key arguments:

We currently limit participation in science to “elite” institutions and individuals, despite the potential for broader involvement.
This exclusion concentrates decision-making power and knowledge in the hands of a few, often driven by self-interest rather than collective progress.
This ultimately harms everyone, regardless of their role in the system (fearing inadequacy, passively consuming knowledge, or self-perceived intellectual superiority).
Call to action:

The author asks for suggestions on how to change the system at various levels (individual, social, political) to create a more inclusive and equitable scientific landscape.

Additional information:

The text includes resources related to open science, citizen science, and democratizing knowledge production.

Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges

Geerts, H., Wikswo, J., van der Graaf, P. H., Bai, J. P., Gaiteri, C., Bennett, D., … & Pelleymounter, M. (2020). Quantitative systems pharmacology for neuroscience drug discovery and development: current status, opportunities, and challenges. CPT: pharmacometrics & systems pharmacology, 9(1), 5-20. https://doi.org/10.1002/psp4.12478

No “Aha” Moments Here…

No “Aha” Moments Here… Last week, the following research headline ran in EurekAlert!, a science news outlet produced by the American Association for the Advancement of Science (AAAS): “Parents of children with complex medical conditions more likely to have mental health issues” You don’t say. Unfortunately, obvious research headers like this one are not uncommon. They … Read more

Who are You? Who am I? And the Problem of Identity Optics

We desperately act in ways that are less and less driven by our real values, and that are increasingly driven by our need to be valued. Maybe that anxious, phrenetic energy undermines our ability to stop, reflect, and think. Maybe the best way that we can do to functionally manage is to seek refuge in the comfort of categorical simplicity and binaries: of dramatic hero-villain narratives. 

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