What is Learning?

Maybe lifelong learning can be best conceptualized as a way of engaging with people and with ideas and that naturally mediates a particular epistemic attitude; that attitude being a loving, non-attachment toward one’s appraisal of knowledge and the process of learning. In other words, learning is a good in itself, uncompromised by the irrational desire to see “oneself” in a certain way. 

If amphetamines exert their effects via G-Protein Coupled Receptors (GPCRs) like TAARs, then doesn’t their use optimize homeostatic mechanisms involved in dopaminergic signaling?

Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders.

Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains Link to direct file Underhill, Suzanne M., et al. “Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains.” Molecular psychiatry 26.4 (2021): 1208-1223. Significance of this work My goal here is to convey the extremely paired … Read more

Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges

Geerts, H., Wikswo, J., van der Graaf, P. H., Bai, J. P., Gaiteri, C., Bennett, D., … & Pelleymounter, M. (2020). Quantitative systems pharmacology for neuroscience drug discovery and development: current status, opportunities, and challenges. CPT: pharmacometrics & systems pharmacology, 9(1), 5-20. https://doi.org/10.1002/psp4.12478

Translational BioInformatics in Mental Health: open access data sources and computational biomarker discovery

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Experiencing your brain: neurofeedback as a new bridge between neuroscience and phenomenology

Keywords: neurophenomenology, neurofeedback, multiscale neural dynamics, downward causation, voluntary action Citation: Bagdasaryan J and Le Van Quyen M (2013) Experiencing your brain: neurofeedback as a new bridge between neuroscience and phenomenology. Front. Hum. Neurosci. 7:680. doi: 10.3389/fnhum.2013.00680 This is an embedded Microsoft Office document, powered by Office.  

Conceptual Competence in Psychiatry: Recommendations for Education and Training (Awais Aftab & Scott Waterman, 2020)

Who are You? Who am I? And the Problem of Identity Optics

We desperately act in ways that are less and less driven by our real values, and that are increasingly driven by our need to be valued. Maybe that anxious, phrenetic energy undermines our ability to stop, reflect, and think. Maybe the best way that we can do to functionally manage is to seek refuge in the comfort of categorical simplicity and binaries: of dramatic hero-villain narratives. 

The Role of the Spatial Boundary in Autopoiesis | The Life & Mind Seminar Network

Egbert, M., (2008) https://lifeandmind.wordpress.com/2008/08/21/the-role-of-the-spatial-boundary-in-autopoiesis/ “Figure 2: The spatial boundary here is more accurately represented as a process that enables other processes (dashed arrows). The more appropriate way to include the spatial boundary in this diagram is depicted in figure 2. Here, the spatial boundary is more accurately represented as a process (vertex) that enables other … Read more

The Markov blankets of life: autonomy, active inference and the free energy principle (Michael Kirchhoff, Thomas Parr, Ensor Palacios, Karl Friston and Julian Kiverstein, 2018)

Abstract: This work addresses the autonomous organization of biological systems. Itdoes so by considering the boundaries of biological systems, from individualcells to Home sapiens, in terms of the presence of Markov blankets under theactive inference scheme—a corollary of the free energy principle. A Markovblanket defines the boundaries of a system in a statistical sense. Here we consider how a collective of Markov blankets can self-assemble into a globalsystem that itself has a Markov blanket; thereby providing an illustrationof how autonomous systems can be understood as having layers of nestedand self-sustaining boundaries.

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