If amphetamines exert their effects via G-Protein Coupled Receptors (GPCRs) like TAARs, then doesn’t their use optimize homeostatic mechanisms involved in dopaminergic signaling?

Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains Link to direct file Underhill, Suzanne M., et al. “Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains.” Molecular psychiatry 26.4 (2021): 1208-1223. Significance of this work My goal here is to convey the extremely paired … Read more

What does democratizing science/medicine mean? And, how does that look different from what we’re doing right now?

Overview The advent of advanced digital technologies is a feature of our global landscape that could facilitate the democratic distribution of opportunities for scientific exploration, knowledge production, and consumption in ways that were once thought to be impossible. However, the universal human right to participate in science and engineering is an idea that is understated … Read more

Prescription Drug Monitoring Programs (PDMPs), Prescribing & Dispensing Policies | Do they function to mediate help or harm?

“Overall, opiod prescribing rates have been shown to decrease in some states after implementation of PDMPs, but no significant changes have been found in others. Studies on the effects of PDMPs on opiod overdoses have similarly been mixed with some studies finding no chance in overdose following PDMP implementation, and others finding an increase in overdose. In addition, there has been considerable concern among researchers that the rise in heroin use and overdose starting in 2010 may have been an unintended consequence of policies like the PDMP that reduced the supply of prescription opioids for non-medical use.

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