What is Learning?
Maybe lifelong learning can be best conceptualized as a way of engaging with people and with ideas and that naturally mediates a particular epistemic attitude; that attitude being a loving, non-attachment toward one’s appraisal of knowledge and the process of learning. In other words, learning is a good in itself, uncompromised by the irrational desire to see “oneself” in a certain way.
If amphetamines exert their effects via G-Protein Coupled Receptors (GPCRs) like TAARs, then doesn’t their use optimize homeostatic mechanisms involved in dopaminergic signaling?
Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains Link to direct file Underhill, Suzanne M., et al. “Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains.” Molecular psychiatry 26.4 (2021): 1208-1223. Significance of this work My goal here is to convey the extremely paired … Read more
Open Science, Engineering, and Medicine Projects
openlifesci.org/ols-2/projects-participants/
What does democratizing science/medicine mean? And, how does that look different from what we’re doing right now?
Overview The advent of advanced digital technologies is a feature of our global landscape that could facilitate the democratic distribution of opportunities for scientific exploration, knowledge production, and consumption in ways that were once thought to be impossible. However, the universal human right to participate in science and engineering is an idea that is understated … Read more
Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges
Geerts, H., Wikswo, J., van der Graaf, P. H., Bai, J. P., Gaiteri, C., Bennett, D., … & Pelleymounter, M. (2020). Quantitative systems pharmacology for neuroscience drug discovery and development: current status, opportunities, and challenges. CPT: pharmacometrics & systems pharmacology, 9(1), 5-20. https://doi.org/10.1002/psp4.12478
Translational BioInformatics in Mental Health: open access data sources and computational biomarker discovery
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Beyond antipsychotics: a twenty-first century update for preclinical development of schizophrenia therapeutics
Spark, D.L., Fornito, A., Langmead, C.J. et al. Beyond antipsychotics: a twenty-first century update for preclinical development of schizophrenia therapeutics. Transl Psychiatry 12, 147 (2022). https://doi.org/10.1038/s41398-022-01904-2 This is an embedded Microsoft Office document, powered by Office.
