Higher Morbidity & Mortality Associated with Prescription Drug Monitoring Programs in 3 States | What is the Problem We Are Trying To Solve Again?

Effects of Implementation and Enforcement Differences in Prescription Drug Monitoring Programs in 3 States: Connecticut, Kentucky, and Wisconsin   Before analyzing the outcomes of the implementation of PDMPs and related drug control policies, let’s back track to the ‘problem’ for which these public health interventions were created to address: “Drug Misuse” is commonly defined as … Read more

Article 27

  What is Article 27? The Universal Declaration of Human Rights, adopted by the UN General Assembly on 10 December 1948, includes an article that supports the human right to participate in science through education, advocacy, and the development of open tools for self-research. This article, known as Article 27, has been largely neglected but … Read more

What is Learning?

Maybe lifelong learning can be best conceptualized as a way of engaging with people and with ideas and that naturally mediates a particular epistemic attitude; that attitude being a loving, non-attachment toward one’s appraisal of knowledge and the process of learning. In other words, learning is a good in itself, uncompromised by the irrational desire to see “oneself” in a certain way. 

If amphetamines exert their effects via G-Protein Coupled Receptors (GPCRs) like TAARs, then doesn’t their use optimize homeostatic mechanisms involved in dopaminergic signaling?

Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders.

Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains Link to direct file Underhill, Suzanne M., et al. “Amphetamines signal through intracellular TAAR1 receptors coupled to Gα13 and GαS in discrete subcellular domains.” Molecular psychiatry 26.4 (2021): 1208-1223. Significance of this work My goal here is to convey the extremely paired … Read more

What does democratizing science/medicine mean? And, how does that look different from what we’re doing right now?

The current state of science and technology excludes many individuals from participating, despite the potential for technology to democratize these fields. This exclusion perpetuates inequities and undermines the scientific enterprise itself.

Key arguments:

We currently limit participation in science to “elite” institutions and individuals, despite the potential for broader involvement.
This exclusion concentrates decision-making power and knowledge in the hands of a few, often driven by self-interest rather than collective progress.
This ultimately harms everyone, regardless of their role in the system (fearing inadequacy, passively consuming knowledge, or self-perceived intellectual superiority).
Call to action:

The author asks for suggestions on how to change the system at various levels (individual, social, political) to create a more inclusive and equitable scientific landscape.

Additional information:

The text includes resources related to open science, citizen science, and democratizing knowledge production.

Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges

Geerts, H., Wikswo, J., van der Graaf, P. H., Bai, J. P., Gaiteri, C., Bennett, D., … & Pelleymounter, M. (2020). Quantitative systems pharmacology for neuroscience drug discovery and development: current status, opportunities, and challenges. CPT: pharmacometrics & systems pharmacology, 9(1), 5-20. https://doi.org/10.1002/psp4.12478

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